Voprosy meditsinskoi khimii (ISSN 0042-8809)

Reconstitution of cytochrome oxidase with liver and hepatoma 27 mitochondrial lipids

   
Kondrashin A.A., Berezov T.T.
PubMed Id: 6256959
Year: 1980 vol: 26  issue:3  pages: 334-339
Abstract: Activity of cytochrome oxidase, incorporated into the lipoprotein vesicles /proteoliposomes/ in the course of self assembly procedure, was studied. For this purpose the lipids were used, which were isolated from mitochondria of rat liver tissue and of hepatoma 27. The enzymatic activity was distinctly increased after the reconstriction using liver mitochondrial phospholipids; the hepatoma lipids were not effective. An agent uncoupling the oxidative phosphorylation activated the oxygen utilization by cytochrome oxidase in proteoliposomes containing phospholipids of liver mitochondria, but not of hepatoma organelles. A difference in electrical potentials, generated by cytochrome oxidase reaction on proteoliposome membranes containing the phospholipids from liver mitochondria, was distinctly higher as compared with proteoliposomes containing the lipids from mitochondria of tumors.
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Reference: Kondrashin A.A., Berezov T.T., Reconstitution of cytochrome oxidase with liver and hepatoma 27 mitochondrial lipids, Voprosy meditsinskoi khimii, 1980, vol: 26(3), 334-339.
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