Voprosy meditsinskoi khimii (ISSN 0042-8809)

Role of 5-alpha-androstane-3-beta, 17-beta-diol in establishing feedback between the gonads and hypothalamo-hypophyseal system of orchidectomized adult rats

   
Loseva L.A., Degtiar' V.G., Isachenkov V.A.
PubMed Id: 7006206
Year: 1980 vol: 26  issue:3  pages: 398-402
Abstract: Concentration of luteinizing hormone and content of luliberine were estimated, respectively, blood serum and in hypothalamic arccuate nucleus and median eminence of adult castrated rats after administration of testosterone, 5 alpha-androstane 3 beta, 17 beta diol and 5 alpha-androstane 3 alpha, 17 beta diol. Effect of testosterone and of its derivatives on hypothalamo-hypophysial system was distinctly dissimilar both in the intensity of the action and in the rate of its realization. 5 alpha-androstane 3 beta, 17 beta diol as well as testosterone and 5 alpha-androstane 3 alpha, 17 beta diol were shown to be active in the negative feedback mechanism between gonads and hypothalamo-hypophysial system; the effect of androgenes was dose-dependent.
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Reference: Loseva L.A., Degtiar' V.G., Isachenkov V.A., Role of 5-alpha-androstane-3-beta, 17-beta-diol in establishing feedback between the gonads and hypothalamo-hypophyseal system of orchidectomized adult rats, Voprosy meditsinskoi khimii, 1980, vol: 26(3), 398-402.
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