Voprosy meditsinskoi khimii (ISSN 0042-8809)

Adenylate cyclase system and calcium transport in the cardiac muscle of normal rabbits and rabbits with allergic heart damage

   
Grozdova M.D., Grigorovich I.A., Zubovskaia A.M., Miroshnichenko V.P., Sharlova I.L.
PubMed Id: 7456376
Year: 1980 vol: 26  issue:3  pages: 415-421
Abstract: A 2,3-fold increase of cAMP concentration in rabbit myocardium, increase in basal activity of adenylate cyclase and inhibition of phosphodiesterase were found in allergic impairment of heart muscle in response to repeated administration of normal horse blood serum. In presence of adrenaline and NaF the rate of adenylate cyclase activation was distinctly decreased, indicating the "desensitization" of the enzyme. At the same time, parameters of Ca2+ transport were altered; the alterations were expressed as intensification of 45Ca turnover in mitochondria and in the fraction of sarcoplasmic reticulum, as well as distinct increase in the initial rate of Ca2+ penetration into mitochondria and increase in content of calcium in the organelles.
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Reference: Grozdova M.D., Grigorovich I.A., Zubovskaia A.M., Miroshnichenko V.P., Sharlova I.L., Adenylate cyclase system and calcium transport in the cardiac muscle of normal rabbits and rabbits with allergic heart damage, Voprosy meditsinskoi khimii, 1980, vol: 26(3), 415-421.
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