Voprosy meditsinskoi khimii (ISSN 0042-8809)

Aspartate aminotransferase activity in the brain and spinal cord in acute and chronic alcoholic intoxication

   
Veksler I.I., Magomedova K.M.
PubMed Id: 7192905
Year: 1980 vol: 26  issue:4  pages: 438-442
Abstract: Resynthesis of aspartate via glutamate was decreased 6-8-fold in rat brain spinal cord tissues due to distinct inhibition of aspartate aminotransferase in acute alcohol intoxication. Consumption of glutamic acid was distinctly increased 1.5-2-fold in tissues of the central nervous system but its metabolism was altered. Normalization occurred within 12-24 hrs after the intake of alcohol. In the state of chronic alcohol intoxication the enzymatic activity was marked increased in brain and spinal cord; in this case the response to a single alcohol administration was altered as compared with acute alcohol intoxication.
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Reference: Veksler I.I., Magomedova K.M., Aspartate aminotransferase activity in the brain and spinal cord in acute and chronic alcoholic intoxication, Voprosy meditsinskoi khimii, 1980, vol: 26(4), 438-442.
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