Voprosy meditsinskoi khimii (ISSN 0042-8809)

Plasma protein and cerebral soluble protein disc electrophoresis in Down's syndrome

   
Baryshevskaia G.D., Mikhneva L.M., Usova I.I.
PubMed Id: 6450483
Year: 1980 vol: 26  issue:4  pages: 480-484
Abstract: Blood plasma proteins and soluble proteins from brain lobus frontalis of patients with mongolism were studied using polyacrylamide gel disc electrophoresis. A decrease in content of albumins, proteins of Gc system, transferrine, fast posttransferrines and an increase in amount of immunoglobulin proteins as well as of alpha 2-macroglobulin were observed in the preparations of blood plasma proteins. These alterations were apparently determined by impairments in functions of protein-synthesizing systems. Content of four different protein fractions was altered as shown by brain proteinogramms.
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Reference: Baryshevskaia G.D., Mikhneva L.M., Usova I.I., Plasma protein and cerebral soluble protein disc electrophoresis in Down's syndrome, Voprosy meditsinskoi khimii, 1980, vol: 26(4), 480-484.
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