Voprosy meditsinskoi khimii (ISSN 0042-8809)

Changes in oxidative phosphorylation in rat liver mitochondria during the development of cholestasis

   
Konstantinov I.M., Filippova S.N., Vavilin V.A., Panov A.V., Liakhovich V.V.
PubMed Id: 7456389
Year: 1980 vol: 26  issue:4  pages: 498-502
Abstract: Kinetic patterns of oxydative phosphorylation were studied in rat liver mitochondria in dynamics of cholestasis and after addition of bile acids to mitochondria in vitro. Within the 1 and 3 days of cholestasis mitochondrial synthesis of ATP was decreased due to inhibition of ATP and ADP transport by the bile acids. At the period within 3 and 15 days uncoupling of the oxidative phosphorylation occurred; the phenomenon observed might be a result of impairment in the structure of inner mitochondrial membrane.
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Reference: Konstantinov I.M., Filippova S.N., Vavilin V.A., Panov A.V., Liakhovich V.V., Changes in oxidative phosphorylation in rat liver mitochondria during the development of cholestasis, Voprosy meditsinskoi khimii, 1980, vol: 26(4), 498-502.
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