Voprosy meditsinskoi khimii (ISSN 0042-8809)

Catalytic properties of the monooxygenases that oxidize 14C-phenazepam

   
Golovenko N.Ya., Meteshkin I.V., Iakubovskaia L.N.
PubMed Id: 6106980
Year: 1980 vol: 26  issue:5  pages: 637-640
Abstract: Aromatic hydroxylation and oxidation of heterocyclic molecule of phenazepame were studied. The reaction of aromatic hydroxylation prevailed in microsomes of intact animals, whereas preinduction of rats using phenobarbital and 3-methylcholanthrene altered the phenazepame metabolism increasing the rate of oxidation in the heterocyclic ring. Kinetic parameters are described for oxidation of phenazepame molecule by both intact and induced rat microsomes.
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Reference: Golovenko N.Ya., Meteshkin I.V., Iakubovskaia L.N., Catalytic properties of the monooxygenases that oxidize 14C-phenazepam, Voprosy meditsinskoi khimii, 1980, vol: 26(5), 637-640.
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