Voprosy meditsinskoi khimii (ISSN 0042-8809)

Change in the cyclic nucleotide system components in neurogenic myopathies

   
Khokhlov A.P., Malakhovskiĭ V.K.
PubMed Id: 6252689
Year: 1980 vol: 26  issue:5  pages: 640-643
Abstract: Values of Kdiss of the "protein kinase-cAMP" complex were decreased 2-6-fold in muscular tissue of patients with neurogenic myopathies. An increase in affinity of the protein kinase to cAMP correlated with the severity of the disease. Alteration in the cAMP-sGMP ratio, due to decrease in cGMP content, was found in patients with side amyotrophic sclerosis.
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Reference: Khokhlov A.P., Malakhovskiĭ V.K., Change in the cyclic nucleotide system components in neurogenic myopathies, Voprosy meditsinskoi khimii, 1980, vol: 26(5), 640-643.
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