Voprosy meditsinskoi khimii (ISSN 0042-8809)

Mechanism of the activating action of noradrenaline on rat cerebral cortex Na, K-ATPase

   
Pikulev A.T., Shcherban' A.I.
PubMed Id: 6252690
Year: 1980 vol: 26  issue:5  pages: 671-673
Abstract: Effect of noradrenaline on kinetics of Na, K-ATPase activation in rat brain cortex was studied using ATP as a substrate and Na+ or K+ ions as cofactors. Noradrenaline (5 x 10(-5) M) increased the activating effect of ATP and Mg2+ as well as that of Na+ and K+. In presence of ATP and Mg2+ the hormone activated ATPase by the mixed type, and in response to Na+, K+ addition--by the non-competitive type. Noradrenaline appears to cause the conformational alterations in Na, K-ATPase molecule, which change the kinetics of the enzyme activation by ATP and the ions.
Download PDF:
Reference: Pikulev A.T., Shcherban' A.I., Mechanism of the activating action of noradrenaline on rat cerebral cortex Na, K-ATPase, Voprosy meditsinskoi khimii, 1980, vol: 26(5), 671-673.
References
 1985(Vol:31)
 1984(Vol:30)
 1983(Vol:29)
 1982(Vol:28)
 1981(Vol:27)
 1980(Vol:26)
 1979(Vol:25)
 1978(Vol:24)
 1977(Vol:23)
 1976(Vol:22)