Voprosy meditsinskoi khimii (ISSN 0042-8809)

Action of remantadine on virus-specific polypeptide synthesis in a Sindbis virus-infected cell culture

   
Lazymova Z.A., Linitskaia G.L., Leont'eva N.A., Galegov G.A.
PubMed Id: 7423886
Year: 1980 vol: 26  issue:5  pages: 677-679
Abstract: Effect of remantadine (alpha-methyl-I-adamantane methylamine) on reproduction and synthesis of the virus-specific polypeptides was studied in culture of chicken embryo fibroblasts, infected with virus Syndbis. The preparation inhibited the virus reproduction as well as the formation of virus-specific proteins after addition into the cultural medium together with virus, immediately after absorption and within 1 and 2 hrs after absorption. The data obtained suggest a possibility of an immediate effect of remantadine on the synthesis of virus-specific macromolecules.
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Reference: Lazymova Z.A., Linitskaia G.L., Leont'eva N.A., Galegov G.A., Action of remantadine on virus-specific polypeptide synthesis in a Sindbis virus-infected cell culture, Voprosy meditsinskoi khimii, 1980, vol: 26(5), 677-679.
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