Voprosy meditsinskoi khimii (ISSN 0042-8809)

Changes in prostaglandin systhetase activity in mouse tissues as affected by S-N-(3-aminopropyl)-2-aminoethyl thiophosphoric acid

   
Prianishnikova E.N., Zhulanova Z.I., Romantsev E.F.
PubMed Id: 6252692
Year: 1980 vol: 26  issue:5  pages: 685-688
Abstract: Effect of various concentrations of a radioprotector S-[N-(3 aminopropyl)-2-aminoethyl] thiophosphoric acid on the activity of prostaglandine synthetase was studied in mouse liver microsomes as well as in the soluble fractions of testicules and brain in vitro. The activity of prostaglandine synthetase was estimated by monitoring the formation of labelled PGF2 alpha and PGE2 from I-14C-arachidonic acid. The radioprotector at concentration 1.66 mg/ml stimulated formation of PGF2 alpha in all the tissues studied. At the lower concentrations of the radioprotector only slight stimulation of the biosynthesis of prostaglandines in testicules was noted. No effect on their synthesis in the brain soluble fraction could be observed while in the liver microsomes it was inhibited. The radioprotective substance studied apparently affected the cyclooxygenase activity, which is a key enzyme in the prostaglandine-synthesizing system.
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Reference: Prianishnikova E.N., Zhulanova Z.I., Romantsev E.F., Changes in prostaglandin systhetase activity in mouse tissues as affected by S-N-(3-aminopropyl)-2-aminoethyl thiophosphoric acid, Voprosy meditsinskoi khimii, 1980, vol: 26(5), 685-688.
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