Voprosy meditsinskoi khimii (ISSN 0042-8809)

Apoprotein A-1 in high-density lipoprotein subfractions and lecithin-cholesterol-acyltransferase activity in hyperalphacholesterinemia

   
Perova N.V., Metel'skaia V.A., Ozerova I.N., Gadzhalova S.I., Chernysheva N.P.
PubMed Id: 7423887
Year: 1980 vol: 26  issue:5  pages: 688-694
Abstract: Content of apolipoprotein (apo A-I) was studied in subfractions of high density lipoproteins (HDL) using quantitative "rocket" immunoelectrophoresis in two groups of men with the level of LPHD cholesterol within 70 mg/dl (27 patients) and above 70 mg/dl (15 patients). An increase in content of cholesterol from HDL2 subfraction and activation of lecithine-cholesterol acyltransferase in hyper-alpha-cholesterolemia (hyper-alpha-lipoproteinemia) were mainly due to elevation in both absolute amount of apo A-I containing in HDL2 of blood plasma and in relative part of apo A-I in HDL2 of blood plasma and in relative part of apo A-I in HDL2. But contrary to the observation, content of apo A-I from HDL3 subfraction was decreased in the impairment. In aggrement with the modern hypothesis on the antiatherogenic nature of hyper-alpha-lipoproteinemia, the impairment is related to intensification of the cholesterol-acceptor function of HDL due to the activating effect of apolipoprotein A-I (content of which is increased in HDL2) on lecithine-cholesterol acyltransferase in vivo.
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Reference: Perova N.V., Metel'skaia V.A., Ozerova I.N., Gadzhalova S.I., Chernysheva N.P., Apoprotein A-1 in high-density lipoprotein subfractions and lecithin-cholesterol-acyltransferase activity in hyperalphacholesterinemia, Voprosy meditsinskoi khimii, 1980, vol: 26(5), 688-694.
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