Voprosy meditsinskoi khimii (ISSN 0042-8809)

Enzymes of citrate and isocitrate conversion in the heart and skeletal muscle mitochondria of embryos and adult rabbits

   
Sharkova E.V.
PubMed Id: 7423888
Year: 1980 vol: 26  issue:5  pages: 694-698
Abstract: Activities of citrate synthase, aconitase, NAD- and NADP-dependent isocitrate dehydrogenases were studied in mitochondria of heart and skeletal muscles of embryos and adult rabbits. Activity of these enzymes was some times lower in embryonal skeletal muscles as compared with the muscles of adult animals. Differences in activities of citrate synthase, aconitase and NADP-dependent isocitrate dehydrogenase were unsignificant in heart muscles of embryos and adult animals. Activity of NAD-dependent isocitrate dehydrogenase was distinctly higher in embryonal heart than in adult rabbits. The kinetic parameters enabled to conclude that in vitro regulation of NAD-dependent oxidation of isocitrate by substrate and activator ADP, characteristic for the enzyme from tissues of adult animals, was also found in embryos.
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Reference: Sharkova E.V., Enzymes of citrate and isocitrate conversion in the heart and skeletal muscle mitochondria of embryos and adult rabbits, Voprosy meditsinskoi khimii, 1980, vol: 26(5), 694-698.
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