Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of experimental myocardial infarct on the rate of NADH and 3-hydroxybutyrate oxidation in heart mitochondria

   
Dzheia P.P., Toleikis A.I., Prashkiavichius A.K.
PubMed Id: 7456403
Year: 1980 vol: 26  issue:6  pages: 731-735
Abstract: The rate of oxidation of NADH and 3-hydroxybutyrate was studied in heart mitochondria after short-term (60 min) occlusion of coronary artery and the subsequent reperfusion. Addition of NAD increased the rate of 3-hydroxybutyrate oxidation, lowered in mitochondria of impaired tissue, but no complete restoration occurred. Th 3-hydroxybutyrate dehydrogenase activity was decreased by 25%. The rate of NADH oxidation in ultrasonicated mitochondria from the infarction zone exceeded 2-fold the rate of 3-hydroxybutyrate oxidation. These data suggest that deficiency of NAD limited primarily the rate of 3-hydroxybutyrate oxidation in heart mitochondria under conditions of experimental myocardial infarction. The level of 3-hydroxybutyrate dehydrogenase activity appears to restrict the rate of 3-hydroxybutyrate oxidation after addition of NAD.
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Reference: Dzheia P.P., Toleikis A.I., Prashkiavichius A.K., Effect of experimental myocardial infarct on the rate of NADH and 3-hydroxybutyrate oxidation in heart mitochondria, Voprosy meditsinskoi khimii, 1980, vol: 26(6), 731-735.
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