Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of the kallikrein-like enzyme salivain on the course of experimental acute parotitis

   
Kovalenko A.F., Levitskiĭ A.P.
PubMed Id: 7006208
Year: 1980 vol: 26  issue:6  pages: 750-752
Abstract: Mechanical trauma of rat parotid gland led to an increase in the size of the gland (due to edema) with simultaneous activation of unspecific proteases, which were estimated at pH 7.6 using casein as a substrate. Administration of kallikrein-like salivary enzyme salivain into non-traumatized parotid gland caused also the same alterations. Complex application of two factors (trauma and salivain) resulted in distinct increase of the gland edema and the proteolytic activity. Administration of trasilol (inhibitor of proteases) decreased the pathogenic effects of salivain. After administration of salivain the alkaline phosphatase activity was shown to decrease in the parotid salivary gland.
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Reference: Kovalenko A.F., Levitskiĭ A.P., Effect of the kallikrein-like enzyme salivain on the course of experimental acute parotitis, Voprosy meditsinskoi khimii, 1980, vol: 26(6), 750-752.
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