Voprosy meditsinskoi khimii (ISSN 0042-8809)

Activation of 14C-n-hydroxybenzoate and 2-14C-mevalonate incorporation into ubiquinone in regenerating rat liver

   
Fedurov V.V.
PubMed Id: 7456407
Year: 1980 vol: 26  issue:6  pages: 759-763
Abstract: Incorporation of 14C-p-hydroxybenzoate and 2-14C-mevalonate into ubiquinone in vivo and in vitro was distinctly increased in regenerating rat liver lobes within 1st and 2nd day after partial hepatectomy, whereas incorporation of 2-14C-mevalonate into sterols was unaltered. The stimulation observed was partially due to an increase in the rate of biosynthesis of the enzymes, catalysing the incorporation of the label into the ubiquinone. Preliminary administration of cholesterol or cholesterol with bile into rats caused an inhibition of the multistep biosynthesis of sterols at several sites and stimulated the ubiquinone synthesis. Intravenous administration of ubiquinone-9 emulsion was accompanied by more than 3-fold increase in concentration of the substance in regenerating liver tissue and did not cause any effect on the rate of incorporation of 14C-p-hydroxybenzoate and 14-C-methyl methionine into slices, obtained from this tissue.
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Reference: Fedurov V.V., Activation of 14C-n-hydroxybenzoate and 2-14C-mevalonate incorporation into ubiquinone in regenerating rat liver, Voprosy meditsinskoi khimii, 1980, vol: 26(6), 759-763.
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