Voprosy meditsinskoi khimii (ISSN 0042-8809)

Cyclic 3',5'-adenosine monophosphate in the liver of rats with experimental rheumatoid arthritis

   
Iusipova N.A., Goncharik L.A., Balakleevskiĭ A.I., Surikov P.M., Bezkrovnaia V.G.
PubMed Id: 6256964
Year: 1980 vol: 26  issue:6  pages: 767-770
Abstract: Content of cAMP was distinctly decreased in rat liver tissue within the first days of development of experimental rheumatoid arthritis (adjuvant arthritis). Within 6 days the content of cAMP was slightly increased in liver tissue of the arthritic rats but it was lowered 2-fold as compared with controls. The content of cAMP was quite unaltered during subsequent course of the impairment (within 25 days). In blood plasma of patients with rheumatoid arthritis the content of cAMP was decreased more than 2-fold as compared with its concentration in blood of donors. Possible importance of cAMP deficiency in pathogenesis of rheumatoid arthritis is discussed.
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Reference: Iusipova N.A., Goncharik L.A., Balakleevskiĭ A.I., Surikov P.M., Bezkrovnaia V.G., Cyclic 3',5'-adenosine monophosphate in the liver of rats with experimental rheumatoid arthritis, Voprosy meditsinskoi khimii, 1980, vol: 26(6), 767-770.
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