Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of a number of enzyme preparations on the course of experimental parotitis

   
Levitskiĭ A.P., Kovalenko A.F.
PubMed Id: 7456417
Year: 1980 vol: 26  issue:6  pages: 847-851
Abstract: Increase in the weight of rat parotid glands, decrease in the protein concentration and the activity of alpha-amylase with simultaneous activation of the proteolytic enzymes (caseinolytic activity at pH 7.6, activity of cathepsins at pH 5.5) were observed in pyo-traumatic parotiditis. Local administration of the protease inhibitor (contrical) or intramuscular treatment with trypsin showed the positive medical effect--decrease of the gland weight, increase in the protein concentration and in the alpha-amylase activity together with lowering in the activity of proteinases. Intramuscular administration of antimicrobic enzymes (lysozyme, RNase, DNAase) did not affect the pyo-traumatic parotiditis. Application of proteolytic enzymes or their inhibitors is recommended for clinical treatment of parotidites.
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Reference: Levitskiĭ A.P., Kovalenko A.F., Effect of a number of enzyme preparations on the course of experimental parotitis, Voprosy meditsinskoi khimii, 1980, vol: 26(6), 847-851.
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