Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of histones on mouse liver mitochondria cytochrome oxidase activity in vitro and in vivo

   
Risin S.A.
PubMed Id: 6258323
Year: 1981 vol: 27  issue:1  pages: 56-59
Abstract: Histones at concentration of 2-10 micrograms/ml activated the mitochondrial cytochrome oxidase and at concentration of 25 micrograms/ml and higher--inhibited the enzyme in vitro. Cytochrome oxidase was completely inactivated by histones at concentration of 100 mg/microliter and higher. After administration in vivo histones modified the reaction of liver mitochondria in response to the subsequent treatment with a non-ion detergent Triton X-100. Possible pathogenetic importance of the phenomena observed is discussed.
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Reference: Risin S.A., Effect of histones on mouse liver mitochondria cytochrome oxidase activity in vitro and in vivo, Voprosy meditsinskoi khimii, 1981, vol: 27(1), 56-59.
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