Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of lysosomal acid-soluble proteins on the respiratory activity of the granulocytes of healthy subjects and chronic myeloid leukemia patients

   
Rybakova L.P., Tiagotin I.V., Kharchenko M.F.
PubMed Id: 6936972
Year: 1981 vol: 27  issue:1  pages: 80-83
Abstract: A rate of oxygen consumption by granulocytes was measured before cell stimulation and following their stimulation by zymosan in healthy persons and in patients with chronic myelocytic leukemia (CML). The rate of oxygen consumption by granulocytes of donors was higher than that of patients with CML. Addition of lysosomal acid soluble proteins, extracted from normal granulocytes, affected the respiratory activity of stimulated and non-stimulated both normal and leukemic cells, depending upon the protein concentration. The alterations were more marked in granulocytes of donors. Lysosomal acid soluble proteins, extracted from granulocytes of patients with CML did not change the cell respiratory activity.
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Reference: Rybakova L.P., Tiagotin I.V., Kharchenko M.F., Effect of lysosomal acid-soluble proteins on the respiratory activity of the granulocytes of healthy subjects and chronic myeloid leukemia patients, Voprosy meditsinskoi khimii, 1981, vol: 27(1), 80-83.
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