Voprosy meditsinskoi khimii (ISSN 0042-8809)

Nuclease activity of blood serum from healthy persons and from patients with some hematologic impairments

   
Blinov M.N., Luganova I.S., Vladimirova A.D.
PubMed Id: 6944947
Year: 1981 vol: 27  issue:2  pages: 211-215
Abstract: Nuclease activity was studied using as a substrate native RNA as well as synthetic polyribonucleotides polyU and polyU-polyA in blood serum of healthy persons and of patients with leukoses and myelofibrosis. In the hematologic impairments no distinct correlation was observed between the nuclease activity with either native RNA or the polyribonucleotides as substrates. The RNAase activity was markedly increased only under conditions of chronic myeloleukosis, whereas a significant increase in the nuclease activity using polyU was found in 42.8% of the patients with acute leukosis, in 61.5% of the patients with chronic myeloleukosis, in 68,7% of the patients with chronic lympholeukosis and in 77.8% of the patients with myelofibrosis; the elevation in the nuclease activity with polyU-polyA as a substrate observed in 28,5%, 15,4%, 12,5% and 33.3% of the patients, respectively.
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Reference: Blinov M.N., Luganova I.S., Vladimirova A.D., Nuclease activity of blood serum from healthy persons and from patients with some hematologic impairments, Voprosy meditsinskoi khimii, 1981, vol: 27(2), 211-215.
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