Voprosy meditsinskoi khimii (ISSN 0042-8809)

Susceptibility of rat thymocyte subpopulations to thymosine affecting their protein synthesis and dexamethasone receptors

   
Lavrinenko I.A., Shergin S.M., Lozovoi V.P.
PubMed Id: 6269298
Year: 1981 vol: 27  issue:3  pages: 326-330
Abstract: Protein synthesis and reception for 1,2-3H-(N)-dexamethasone were studied in A, B, C, D subpopulations of rat thymocytes after treatment with thymosine, cyclic adenosine-3,' 5'-monophosphate (cAMP) and caffeine. Thymosine inhibited the 1,2-3H-(N)-dexamethasone reception in rat thymocyte subpopulations A, B and C by 30-40%, stimulated the protein synthesis in A and B fractions by 30% as well as inhibited the synthesis in D fraction by 14%. Caffeine, administered together with thymosine, inhibited the protein synthesis by 80% in C and D thymocyte subpopulations and - by 47% in B subpopulations. After simultaneous treatment with exogenous cAMP, thymosine and caffeine the protein synthesis was inhibited by 14% in all the thymocyte subpopulations. The data obtained suggest that thymosine and caffeine affect the various lymphocyte T subpopulations, dissimilar in their differentiation.
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Reference: Lavrinenko I.A., Shergin S.M., Lozovoi V.P., Susceptibility of rat thymocyte subpopulations to thymosine affecting their protein synthesis and dexamethasone receptors, Voprosy meditsinskoi khimii, 1981, vol: 27(3), 326-330.
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