Effect of the long-term administration of testosterone on induction of cytochrome P-450 in female rat live tissue using phenobarbital | 
 
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| Chistiakov V.V., Prikhod'ko A.Z. | | PubMed Id: 7281573 | | Year: 1981 vol: 27 issue:3 pages: 340-342 | | Abstract: A preadministration of testosterone propionate into rat females within 8 days caused an increase in the inducing effect of phenobarbital (after its single injection) on the content of cytochrome P-450 in liver tissue. The administration of testosterone did not affect the content of the enzyme in liver tissue. A shown in the experiments on phenobarbital induction of the enzyme as a function of duration of testosterone administration, two maximal peaks, within 1 and 8 days, were observed after preadministration of the hormone. The hormone influenced mainly on the rate of the increase in cytochrome P-450 content but not on degree of its induction. | | Download PDF: | | Reference: Chistiakov V.V., Prikhod'ko A.Z., Effect of the long-term administration of testosterone on induction of cytochrome P-450 in female rat live tissue using phenobarbital, Voprosy meditsinskoi khimii, 1981, vol: 27(3), 340-342. | |
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