Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of the long-term administration of testosterone on induction of cytochrome P-450 in female rat live tissue using phenobarbital

   
Chistiakov V.V., Prikhod'ko A.Z.
PubMed Id: 7281573
Year: 1981 vol: 27  issue:3  pages: 340-342
Abstract: A preadministration of testosterone propionate into rat females within 8 days caused an increase in the inducing effect of phenobarbital (after its single injection) on the content of cytochrome P-450 in liver tissue. The administration of testosterone did not affect the content of the enzyme in liver tissue. A shown in the experiments on phenobarbital induction of the enzyme as a function of duration of testosterone administration, two maximal peaks, within 1 and 8 days, were observed after preadministration of the hormone. The hormone influenced mainly on the rate of the increase in cytochrome P-450 content but not on degree of its induction.
Download PDF:
Reference: Chistiakov V.V., Prikhod'ko A.Z., Effect of the long-term administration of testosterone on induction of cytochrome P-450 in female rat live tissue using phenobarbital, Voprosy meditsinskoi khimii, 1981, vol: 27(3), 340-342.
References
 1985(Vol:31)
 1984(Vol:30)
 1983(Vol:29)
 1982(Vol:28)
 1981(Vol:27)
 1980(Vol:26)
 1979(Vol:25)
 1978(Vol:24)
 1977(Vol:23)
 1976(Vol:22)