Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of autolysis on the physico-chemical properties of mammalian skin

   
Nikolaeva S.S., Dubinskaia V.A., Mikhailov A.N., Koroleva O.A.
PubMed Id: 7281578
Year: 1981 vol: 27  issue:3  pages: 362-366
Abstract: Alterations in physico-chemical properties and in content of several biochemical components were found in skin during postmortal storage of the tissue at the temperature 22 degrees and 5 degrees and relative moisture 92%. Within 96-120 hrs of the postmortal storage a decrease in content of hydrate-bound water and of glycosaminoglycans occurred in the tissue. The alterations were accompanied by an increase in temperature of hydrothermic denaturation and in module of elasticity of the skin. As a result of autolysis solubility of collagen in water was increased at 65 degrees and its acid soluble fractions tended to become denatured although the content of hydroxyproline was unaltered. The processes occurring in the skin within the first period after death, might be considered as a two-step sequence: formation of additional interstructural hydrogen bonds and structure transformation of both collagen and glycosaminoglycans due to the effect of proteinases.
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Reference: Nikolaeva S.S., Dubinskaia V.A., Mikhailov A.N., Koroleva O.A., Effect of autolysis on the physico-chemical properties of mammalian skin, Voprosy meditsinskoi khimii, 1981, vol: 27(3), 362-366.
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