Voprosy meditsinskoi khimii (ISSN 0042-8809)

Alteration in content of lipids and lipoproteins in blood of rabbits with experimental allergic polyneuritis and encephalomyelitis

   
Pleskov V.M., Triufanov V.F., Khitnukhin I.L., Konovalov G.V.
PubMed Id: 6169201
Year: 1981 vol: 27  issue:3  pages: 376-380
Abstract: Experimental allergic encephalomyelitis an polyneuritis were caused in male rats of 2.5-3.0 kg body mass of the Shinshilla strain by means of administration into the foot of the animals pads of homogenous basic protein myelin from bovine spinal cord and myelin from bovine sciatic nerve as a mixture containing complete Freund's adjuvant. In the impaired rabbits total fraction of beta- and pre-beta-lipoproteins as well as content of cholesterol and triglycerides were increased in blood. Antibodies against the basic protein myelin were not found in blood of the animals with experimental allergic encephalomyelitis, whereas the titres of these antibodies were increased in the animals with experimental allergic polyneuritis. Complex formation of antibodies with beta- or pre beta-lipoproteins appears to take place in blood of the animals.
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Reference: Pleskov V.M., Triufanov V.F., Khitnukhin I.L., Konovalov G.V., Alteration in content of lipids and lipoproteins in blood of rabbits with experimental allergic polyneuritis and encephalomyelitis, Voprosy meditsinskoi khimii, 1981, vol: 27(3), 376-380.
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