Voprosy meditsinskoi khimii (ISSN 0042-8809)

Role of peroxidation in destruction of membrane lipids under conditions of liver ischemia

   
Dudnik L.B., Bilenko M.V., Alesenko A.V., Mogilevskaia M.P., Burlakova E.B.
PubMed Id: 7281581
Year: 1981 vol: 27  issue:3  pages: 380-383
Abstract: Alterations in phospholipid and fatty acid composition were studied in homogenates, mitochondrial, microsomal and nuclear fractions during intensification of lipid peroxidation under conditions of liver tissue ischemia. Increase in content of lipid hydroperoxides and decrease in content of arachidonic acid were observed in lipids of all the membranes studied. Content of individual phospholipids altered depending on their susceptibility to peroxidation. In ischemia content of total lipids and phospholipids was decreased. The data obtained suggest the important role of peroxidation in impairment of membrane lipids under conditions of ischemia.
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Reference: Dudnik L.B., Bilenko M.V., Alesenko A.V., Mogilevskaia M.P., Burlakova E.B., Role of peroxidation in destruction of membrane lipids under conditions of liver ischemia, Voprosy meditsinskoi khimii, 1981, vol: 27(3), 380-383.
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