Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of chalones from liver tissues of intact rats on DNA synthesis and mitotic activity in hepatocytes of regenerating liver

   
Rodionov V.M., Pospelova A.V., Kuz'micheva N.A., Gorelova N.V.
PubMed Id: 6456597
Year: 1981 vol: 27  issue:3  pages: 405-408
Abstract: Activity of G1 and G2 chalones was found in liver tissue extract. The chalone G1 as compared with the chalone G2 was responsible for longer effect on mitosis of regenerating liver cells. The influence of the chalones was reversible. DNA synthesis was inhibited similarly after treatment of the animals with 1.0, 0.5 or 0.25 mg of the liver tissue extract per 1.0 g of the body mass.
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Reference: Rodionov V.M., Pospelova A.V., Kuz'micheva N.A., Gorelova N.V., Effect of chalones from liver tissues of intact rats on DNA synthesis and mitotic activity in hepatocytes of regenerating liver, Voprosy meditsinskoi khimii, 1981, vol: 27(3), 405-408.
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