Voprosy meditsinskoi khimii (ISSN 0042-8809)

Mechanism of nonenzymatic fibrinolysis

Litvinov V.I., Slabnov I.D., Zubairov D.M.
PubMed Id: 6457444
Year: 1981 vol: 27  issue:4  pages: 478-481
Abstract: Soluble products of unstabilized fibrin lysis, observed in the systems with adrenaline-heparin complexes, urea and plasmin, were studied using electrophoresis in polyacrylamide gel containing sodium dodecylsulfate. Only one fraction of the soluble proteins, similar to the fibrin monomer as shown by the molecular mass value, was found after the treatment in presence of either adrenaline-heparin complexes of urea. Plasmin, however, caused formation of a number of products. Possible mechanisms of fibrin depolymerization with the heparin complexes are discussed.
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Reference: Litvinov V.I., Slabnov I.D., Zubairov D.M., Mechanism of nonenzymatic fibrinolysis, Voprosy meditsinskoi khimii, 1981, vol: 27(4), 478-481.