Voprosy meditsinskoi khimii (ISSN 0042-8809)

Insulin-heparin complex, its physiological properties

Kudriashov B.A., Pytel' Iu.A., Liapina L.A., Baskakova G.M.
PubMed Id: 7027617
Year: 1981 vol: 27  issue:4  pages: 547-552
Abstract: An insulin-heparin complex was obtained in vitro. The hypoglycemic effect of insulin, included into this complex as compared with free insulin, was increased more than 2-fold when it was tested in animals with stable alloxane diabetes. Contrary to insulin, administration of the insulin-heparin complex increased the anticoagulation properties of blood and exhibited the non-enzymatic fibrinolytic activity towards the unstabilized fibrin both in presence or in absence of inhibitors of fibrinolysis, caused by plasmin.
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Reference: Kudriashov B.A., Pytel' Iu.A., Liapina L.A., Baskakova G.M., Insulin-heparin complex, its physiological properties, Voprosy meditsinskoi khimii, 1981, vol: 27(4), 547-552.