Voprosy meditsinskoi khimii (ISSN 0042-8809)

Cyclic adenosine monophosphate in the fatty tissue of breast and lung cancer patients

   
Bershteĭn L.M., Seleznev I.K., Lemekhov V.G.
PubMed Id: 6274096
Year: 1981 vol: 27  issue:5  pages: 607-611
Abstract: Content of cAMP was studied in fatty tissue of 33 patients with tumor of mammary gland, of 27 patients with tumor of lung tissue and of 27 persons (15 men and 12 women), which constituted the control group. A procedure involving competitive binding of the nucleotide with protein was used. The data obtained were related to the size and amount of adipocytes in fatty tissue. The size of adipocytes was distinctly larger and content of cAMP in fatty tissue was slightly lower in patients with tumor of mammary gland as compared with the corresponding controls. With ageing content of fatty tissue cAMP tended to increase in men and to decrease in women. Negative correlation between the content of cAMP in fatty tissue (pM per kg of body mass) and the size of adipocytes, characteristic for the control group, was not found in the patients with the both forms of tumor. Significance of impairments in synthesis of cAMP in adipocytes for development of specific metabolic patterns of adipose tissue in oncological patients is discussed.
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Reference: Bershteĭn L.M., Seleznev I.K., Lemekhov V.G., Cyclic adenosine monophosphate in the fatty tissue of breast and lung cancer patients, Voprosy meditsinskoi khimii, 1981, vol: 27(5), 607-611.
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