Voprosy meditsinskoi khimii (ISSN 0042-8809)

Use of DNA antibodies for detecting DNA radiation injuries in the bone marrow cell nuclei of irradiated animals

   
Mitriaeva N.A., Moskalenko I.P.
PubMed Id: 7032064
Year: 1981 vol: 27  issue:5  pages: 676-679
Abstract: Impairments in DNA from brain stem cell nuclei of X-ray irradiated animals were studied at early steps after irradiation using antibodies to single-stranded DNA. A possibility was shown to detect by means of an immunochemical technique the irradiation-induced impairments of DNA in brain stem cells. Detection of the impairment was possible within 3 hrs after high doses of the irradiation (206.4-258 mCi/kg); after lower doses - within the first hour of the postirradiation period. The immunochemical procedure might be used for early biological detection of the irradiation impairments as well as for estimation of radio-sensitivity of nuclear cells to the effects of irradiation and radioprotectors.
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Reference: Mitriaeva N.A., Moskalenko I.P., Use of DNA antibodies for detecting DNA radiation injuries in the bone marrow cell nuclei of irradiated animals, Voprosy meditsinskoi khimii, 1981, vol: 27(5), 676-679.
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