Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effectiveness of different alpha-tocopherol derivatives in preventing experimental muscular dystrophy in chickens

   
Donchenko G.V., Kovalenko V.N., Makovetskiĭ V.P., Svishchuk A.A.
PubMed Id: 7336651
Year: 1981 vol: 27  issue:6  pages: 760-763
Abstract: Activity of vitamin E and its derivatives--alpha-tocopheryl quinone, its short chain analogue and alpha-tocopheryl acetate also containing short chain molecule were studied during chicken experimental muscular dystrophy. alpha-Tocopheryl quinone containing short chain molecule proved to be the most active substance; similarly to vitamin E the preparation increased the erythrocyte resistance to osmotic haemolysis, distinctly increased the content of ubiquinone and decreased concentration of ubichromenol in the chicken liver tissue as compared with E-deficient animals. At the same time, the content of ubiquinone was unaltered in skeletal muscles. The data obtained suggest that vitamin E could be effectively substituted by its derivatives for prevention an treatment of muscular dystrophy.
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Reference: Donchenko G.V., Kovalenko V.N., Makovetskiĭ V.P., Svishchuk A.A., Effectiveness of different alpha-tocopherol derivatives in preventing experimental muscular dystrophy in chickens, Voprosy meditsinskoi khimii, 1981, vol: 27(6), 760-763.
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