Voprosy meditsinskoi khimii (ISSN 0042-8809)

Kallikrein and prekallikrein content and antitryptic activity in the blood serum in serum hepatitis of varying degrees of severity

   
Iakubovskaia R.I., Malyshev N.A., Farber N.A., Didkovskiĭ N.A., Paskhina T.S.
PubMed Id: 6977940
Year: 1981 vol: 27  issue:6  pages: 804-811
Abstract: Activity of kallikrein, content of prekallikrein, antitryptic and BAEE-esterase activities as well as content of alpha 1-antitrypsin and heparin were studied in blood serum of patients with the B type of serum hepatitis (SH) of various severity. Presence of kallikrein in the active form, increase in content of prekallikrein, distinct increase in BAEE-esterase and antitryptic activities as well as in content of alpha 1-antitrypsin and heparin were observed in blood serum of the patients with middle and severe forms of the impairment. Severe form of the hepatitis complicated with the acute liver encephalopathy was characterized by the radically new state exhibiting further increase in activity of free kallikrein, decrease in content of prekallikrein as well as in BAEE-esterase activity as compared with middle and severe forms of SH not complicated with the acute liver encephalopathy. Immunochemical analyses showed distinct decrease in the content of alpha 1-antitrypsin in blood serum of the patients with SH impaired also by acute liver encephalopathy. Besides, high level of the antitryptic activity was observed in severe forms of the hepatitis both with the encephalopathy and without of its. Further increase in the activity of free heparin was found in all the three forms of SH. Elevation of the antithrombin III inhibitory activity in presence of heparin was apparently responsible for an increase in the antitryptic activity under conditions of severe forms of SH when content of alpha 1-antitrypsin decreased. Activation of the kinin system and decrease in the alpha 1-antitrypsin synthesis, caused by destructive processes in liver tissue, are considered as factors deteriorating the disease development.
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Reference: Iakubovskaia R.I., Malyshev N.A., Farber N.A., Didkovskiĭ N.A., Paskhina T.S., Kallikrein and prekallikrein content and antitryptic activity in the blood serum in serum hepatitis of varying degrees of severity, Voprosy meditsinskoi khimii, 1981, vol: 27(6), 804-811.
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