Voprosy meditsinskoi khimii (ISSN 0042-8809)

Purine base metabolism in the mother-placenta-fetus system in experimental hypoxia

   
Drukker N.A., Pogorelova T.N., Dluzhevskaia T.S.
PubMed Id: 7336656
Year: 1981 vol: 27  issue:6  pages: 811-815
Abstract: In acute deficiency of oxygen inhibition of purine bases turnover as well as degradation of their high molecular precursors occurred in the system mother-placenta-fetus. Acute hypoxia was accompanied by distinct increase in content of adenine, xanthine + + guanine and uric acid in blood of pregnant rats, in placenta and blood of newborn animals. Long-term effect of hypoxia resulted in adaptation of purine metabolism. In this case production of adenosine and adenosine monophosphate was activated.
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Reference: Drukker N.A., Pogorelova T.N., Dluzhevskaia T.S., Purine base metabolism in the mother-placenta-fetus system in experimental hypoxia, Voprosy meditsinskoi khimii, 1981, vol: 27(6), 811-815.
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