Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of hyperbaric oxygenation on homocarnosine metabolism in the brains of rabbits of different ages

   
Krichevskaia A.A., Bondarenko T.I., Malysheva N.V., Pozhematkina I.A.
PubMed Id: 7080473
Year: 1982 vol: 28  issue:2  pages: 125-128
Abstract: Content of homocarnosine and activity of homocarnosine-carnosine synthetase were studied in brain tissue of 1, 7, 14, 21 and 30 days old rabbits under normal state and after treatment with 0.425 mPu of oxygen within 1 hr. The most distinct alterations in the homocarnosine content and the enzymatic activity were observed in rabbit brain at the first month of postnatal life and accompanied development of sight. After hyperbarooxygenation the content of homocarnosine of rabbit brain was decreased in all the age groups studied but, especially (by 60% and 85%, respectively) in brain of 21- and 30 days old animals; the most distinct inhibition (by 71.5%, 81.1% and 92.4%) of homocarnosine-carnosine synthetase activity was observed in brain of 1, 14 and 30 days old rabbits.
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Reference: Krichevskaia A.A., Bondarenko T.I., Malysheva N.V., Pozhematkina I.A., Effect of hyperbaric oxygenation on homocarnosine metabolism in the brains of rabbits of different ages, Voprosy meditsinskoi khimii, 1982, vol: 28(2), 125-128.
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