Voprosy meditsinskoi khimii (ISSN 0042-8809)

Adaptation of skeletal muscle and myocardium to increased motor activity in hypo- and athyroid rats

   
Seene T.P., Alev K.P., Tomson K.E., Viru A.A.
PubMed Id: 6177099
Year: 1982 vol: 28  issue:2  pages: 20-24
Abstract: Changes in contractility and synthesis of protein were studied in different types of muscles of hypo- and athyroid ratts during adaptation to physical exercise. Intensity of the exercises used corresponded to metabolic power output of 70% VO2max. Thyroidectomy caused a significant decrease in Mg2+ activated actomyosin ATPase activity and in content of RNA in myocardium and in fast oxidative-glycogenolytic and glycogenolytic skeletal muscle fibers. Exercises, intensity of which corresponded to metabolic power output of 70% VO2max led to a more distinct decrease in Mg2+ activated actomyosin ATPase activity in fast glycogenolytic muscle fibers, but in fast oxidative-glycogenolytic fibers the enzymatic activity was increased up to the level comparable with that of intact animals. Rhysical working capacity of athyroid rats was lower by 40% as compared with intact trained animals. Hypothyroidism, induced by means of administration of KJ into previously trained rats, caused a decrease in physical working capacity by 25%.
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Reference: Seene T.P., Alev K.P., Tomson K.E., Viru A.A., Adaptation of skeletal muscle and myocardium to increased motor activity in hypo- and athyroid rats, Voprosy meditsinskoi khimii, 1982, vol: 28(2), 20-24.
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