Voprosy meditsinskoi khimii (ISSN 0042-8809)

Features of the regulation of key enzymes involved in glycolysis and the pentosephosphate shunt in tissues with different functional specializations

   
Panin L.E., Tret'iakova T.A., Russkikh G.S., Voitsekhovskaia E.E.
PubMed Id: 6281988
Year: 1982 vol: 28  issue:2  pages: 26-30
Abstract: Under conditions of acute and chronic stress carbohydrate metabolism was decreased in muscles and liver tissue, increased in adrenal glands and unaltered in brain. cAMP at concentration 10(-5)M decreased the rate of glycolysis in liver tissue and increased it slightly in adrenal glands. The inhibitory effect of cAMP was not decreased by 2',3'-AMP and was reversed completely by the protein inhibitor of proteinkinase. cAMP inhibited hexokinase (HK) isoenzymes 2 and 3 as well as glucose-6-phosphate dehydrogenase (G6PD) isoenzymes 1 and 2, activities of HK 1 and G6PD 3 and 4 were unaltered. The decrease in activities of HK and G6PD appears to be related to phosphorylation of proteinkinase; lack of the effect of cAMP in adrenal glands was apparently due to absence of corresponding cAMP-dependent proteinkinase in this tissue.
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Reference: Panin L.E., Tret'iakova T.A., Russkikh G.S., Voitsekhovskaia E.E., Features of the regulation of key enzymes involved in glycolysis and the pentosephosphate shunt in tissues with different functional specializations, Voprosy meditsinskoi khimii, 1982, vol: 28(2), 26-30.
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