Voprosy meditsinskoi khimii (ISSN 0042-8809)

Cortisol inhibition of cholesterol and phospholipid biosynthesis in the rat liver

   
Titov V.N., Sanfirova V.M., Khodakova T.D., Kantardzhian I.G.
PubMed Id: 7113052
Year: 1982 vol: 28  issue:4  pages: 38-42
Abstract: Effect of hydrocortisone on biosynthesis of cholesterol and phospholipids in liver tissue was studied using intact rats, in adrenalectomy, under conditions of stimulation of lipid biosynthesis by cholestyramine and Triton WR-1339. Hydrocortisone was shown to inhibit biosynthesis of cholesterol and phospholipids in rat liver tissue if 2-14C-acetate was used as a precursor. The hormone inhibited biosynthesis of lipid components in membranes of adrenalectomized rats. Under conditions of preactivation of the lipid biosynthesis, using simulation with cholestyramine and Trition WR-1339, hydrocortisone decreased the synthesis of cholesterol and phospholipids.
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Reference: Titov V.N., Sanfirova V.M., Khodakova T.D., Kantardzhian I.G., Cortisol inhibition of cholesterol and phospholipid biosynthesis in the rat liver, Voprosy meditsinskoi khimii, 1982, vol: 28(4), 38-42.
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