Voprosy meditsinskoi khimii (ISSN 0042-8809)

Specificity characteristics of estrogen interaction with the cytoplasmic receptors of the uterus and oviducts in green monkeys (Cercopithecus griseus)

   
Fanchenko N.D., Alekseeva M.L., Sturchak S.V., Novikov E.A.
PubMed Id: 7113055
Year: 1982 vol: 28  issue:4  pages: 56-58
Abstract: The specificity of interaction in Cercopithecus griseus uterus and oviduct cytosol receptor systems with 14 estrogenic substances has been characterized. It was shown that the activity of steroid-receptor interaction was mainly due to presence of hydroxyl groups in C3- and C17b-positions. The nearest environment of these functional groups in molecules affected also the affinity of steroids to the systems investigated. Analysis of the cytosol estrogen-receptor system specificity from Cercopithecus griseus, guinea pig, human uterus and oviduct showed the general pattern of the estrogen binding to the above-mentioned systems. Similarity was also noted between these Cercopithecus griseus and human estrogen-receptor systems.
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Reference: Fanchenko N.D., Alekseeva M.L., Sturchak S.V., Novikov E.A., Specificity characteristics of estrogen interaction with the cytoplasmic receptors of the uterus and oviducts in green monkeys (Cercopithecus griseus), Voprosy meditsinskoi khimii, 1982, vol: 28(4), 56-58.
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