Voprosy meditsinskoi khimii (ISSN 0042-8809)

Anticholinesterase properties and metabolism of new thiophosphonates with a carboxy ester bond in the phosphoryl portion of the molecule

   
Mikhaĭlov S.S.
PubMed Id: 7115520
Year: 1982 vol: 28  issue:4  pages: 79-83
Abstract: Introduction of the carboxyester bond into the phosphoryl part of thiophosphonate molecules did not affect their capacity to inhibit cholinesterases, but increased the rate of enzymatic detoxication of the preparations. The enzymatic turnover of the drugs studied occurred in rat tissues mainly be means of hydrolysis of the complex-ester bond. The carboxyesterase hydrolysis of these drugs was apparently carried out involving the unspecific enzyme aliesterase (EC 3.1.1.1.).
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Reference: Mikhaĭlov S.S., Anticholinesterase properties and metabolism of new thiophosphonates with a carboxy ester bond in the phosphoryl portion of the molecule, Voprosy meditsinskoi khimii, 1982, vol: 28(4), 79-83.
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