Voprosy meditsinskoi khimii (ISSN 0042-8809)

Various hormonal and metabolic disorders in liver cytosol during compensated and decompensated experimental stress

   
Bobkov A.I., Bobkova A.S., Marchenko V.V., Smagin V.G.
PubMed Id: 6129746
Year: 1982 vol: 28  issue:5  pages: 10-13
Abstract: Alterations of glucocorticoid-receptor interactions in liver cytosol and their importance in cell metabolic impairments were studied under various conditions of experimental stress. The experimental stress caused by acute peritonitis developed in rat males of Wistar strain. The alterations in steroid-receptor interactions, observed in liver cells under the stress conditions, might be responsible for adaptation of the cells and affect distinctly the metabolic reactions, inhibiting the early exhaustion of energy substrates in a cell (the stress compensated form). In severe stress reaction an excess of endogenous corticosterone, accumulated in hepatocyte cytosol, might deteriorate the cell metabolism by means of hormonal-receptor system, as a result of which exhaustion of energy potential led to death (decompensated form of the stress).
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Reference: Bobkov A.I., Bobkova A.S., Marchenko V.V., Smagin V.G., Various hormonal and metabolic disorders in liver cytosol during compensated and decompensated experimental stress, Voprosy meditsinskoi khimii, 1982, vol: 28(5), 10-13.
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