Voprosy meditsinskoi khimii (ISSN 0042-8809)

Parameters of interaction of nitrophenols with different chemical structure with albumin, and their toxicity

   
Luik A.I., Luk'ianchuk V.D.
PubMed Id: 7179833
Year: 1982 vol: 28  issue:5  pages: 48-51
Abstract: Chemical structure of a series of nitrophenols and their derivatives was studied in relation to their toxicity and complex-formation ability (association constant, amount of binding sites) with human blood serum albumin. Five compounds were studied using equilibrium dialysis and spectrofluorimetry. The nitrophenols, containing a hydrocarbon radical, exhibited distinctly higher affinity to albumin; substitution of one or two nitrogroups by aminogroups led to complete loss of the affinity to the protein. Dependence of acute toxicity on association constants of the complexes is discussed.
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Reference: Luik A.I., Luk'ianchuk V.D., Parameters of interaction of nitrophenols with different chemical structure with albumin, and their toxicity, Voprosy meditsinskoi khimii, 1982, vol: 28(5), 48-51.
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