Voprosy meditsinskoi khimii (ISSN 0042-8809)

Formation of an organic matrix in the traction method of bone regeneration and characteristics of its mineralization in experimental tibia lengthening

   
Ilizarov G.A., Matveenko V.N., Gaidamak A.N., Ir'ianov Iu.M.
PubMed Id: 7157720
Year: 1982 vol: 28  issue:6  pages: 27-33
Abstract: Stretching of dog crus was carried out using transbone distractional osteosynthesis method by Ilizarov. Distribution of calcium, phosphorus and organic substances in zones of regenerating tissue was studied within 1 and 2 months after stretching and within 2 months after the subsequent fixation of the leg in the apparatus. Zones of non-mineralized osteoids were not found already during destruction. In the zones content of minerals varied only slightly and the less mineralized middle zone contained about 66% of calcium and phosphorus as compared with their level in mature compact bone tissue. Crystals of hydroxyapatite were found in zones close to bone fragments using electron microscopy. The data obtained suggest that under optimal conditions of regeneration provided by the method the newly formed bone matrix is partially mineralized during its synthesis. Reverse correlation was detected between contents of minerals and glycosaminoglycans. Middle zones with a slightly higher concentration of glycosaminoglycans were less mineralized. Within 2 months after stopping of distraction differences between zones were decreased, content of glycosaminoglycans was lowered as minerals accumulated; content of minerals became higher than in spongy bone tissue but slightly lower as compared with compact bone.
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Reference: Ilizarov G.A., Matveenko V.N., Gaidamak A.N., Ir'ianov Iu.M., Formation of an organic matrix in the traction method of bone regeneration and characteristics of its mineralization in experimental tibia lengthening, Voprosy meditsinskoi khimii, 1982, vol: 28(6), 27-33.
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