Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of antiestrogen and antiandrogen derivatives of acylhydrazines on properties of nucleoside triphosphatases and adenyl nucleotide content of nuclei of normal and tumor cells

   
Tret'iakov A.V., Ratovitskii E.A., Petrov A.S., Golovatova V.A.
PubMed Id: 6301157
Year: 1983 vol: 29  issue:1  pages: 98-102
Abstract: Influence of antiestrogen and antiandrogen derivatives of acylhydrazine, potentiating the antitumoral effect of cytostatics, on properties of nucleoside triphosphatases (NTPases), adenylate content in nuclea of normal and tumoral cells was studied. It was shown that acylhydrazines activated specifically the intranuclear NTPase of normal and tumoral cells. Activity of nuclear membrane-linked NTPases from liver cells was also increased after administration of acylhydrazines, sex hormones or phenobarbital. The increase in activity of intranuclear NTPase (namely ATPase) correlated with decrease of adenylates (ADP, ATP) in nuclea isolated from tumors after simultaneous treatment with acylhydrazines and thiophosphamide. Distinct increase in sensitivity of tumoral cell DNA to the effect of these alkylating preparations appear to be due to noncompensated decrease in content of ATP.
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Reference: Tret'iakov A.V., Ratovitskii E.A., Petrov A.S., Golovatova V.A., Effect of antiestrogen and antiandrogen derivatives of acylhydrazines on properties of nucleoside triphosphatases and adenyl nucleotide content of nuclei of normal and tumor cells, Voprosy meditsinskoi khimii, 1983, vol: 29(1), 98-102.
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