Voprosy meditsinskoi khimii (ISSN 0042-8809)

Interrelationship between activity of nuclear ribonucleotide reductase and DNA synthesis of hepatocyte nuclei during liver tissue regeneration

   
Khatsernova B.Ia., Silaeva S.A., Sheremet'evskaia T.N.
PubMed Id: 6344423
Year: 1983 vol: 29  issue:2  pages: 60-64
Abstract: Dynamics of 3H-thymidine incorporation into nuclear DNA and activity of nuclear ribonucleotide reductase were studied within 2 days after partial hepatectomy. The curves describing dynamics of DNA synthesis and the activity of ribonucleotide reductase were of wave-shaped pattern. Maximal enzymatic activity was reached 2 hrs before the nuclear DNA synthesis maximum. An inhibitor of ribonucleotide reductase was found in the globulin fraction of intact liver nuclei; after addition of the inhibitor the activity of the enzyme was decreased 4-5-fold, if the ratio of protein in preparations inhibitor/enzyme was as high as 1:40.
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Reference: Khatsernova B.Ia., Silaeva S.A., Sheremet'evskaia T.N., Interrelationship between activity of nuclear ribonucleotide reductase and DNA synthesis of hepatocyte nuclei during liver tissue regeneration, Voprosy meditsinskoi khimii, 1983, vol: 29(2), 60-64.
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