Voprosy meditsinskoi khimii (ISSN 0042-8809)

Characteristics of integration of monkey adenovirus SA7 DNA fragments with genomes of transformed and tumoral cells

   
Chaplygina N.M., Gartel' A.L., Ponomareva T.I., Tiunnikov G.I., Tikhonenko T.I.
PubMed Id: 6308902
Year: 1983 vol: 29  issue:3  pages: 14-22
Abstract: Transformed rat cells and hamster tumoral cells, obtained after treatment with DNA of monkey adenovirus SA7 which was fragmented using endonuclease SalI, contained all the SalI fragments of SA7 DNA integrated with the cell genomes. As shown by blotting hybridization distinct deletion did not form in the fragments of viral DNA on integration. Insertion of the SA7 DNA fragments appears to occur into the definite relatively small site of the cell chromosome. In the both cell strains studied a site of the SA7 genome transcribed at coordinates: 1.8-10 units of the physical map. Fragments of viral DNA were methylated in the sites CmCGG and CCmCGGG of these both strains studied.
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Reference: Chaplygina N.M., Gartel' A.L., Ponomareva T.I., Tiunnikov G.I., Tikhonenko T.I., Characteristics of integration of monkey adenovirus SA7 DNA fragments with genomes of transformed and tumoral cells, Voprosy meditsinskoi khimii, 1983, vol: 29(3), 14-22.
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