Voprosy meditsinskoi khimii (ISSN 0042-8809)

Absence of a gene dose effect for collagen type I and III in fibroblasts with trisomy of chromosome 7 from a spontaneously aborted human fetus

   
Del'vig A.A., Kukharenko V.I., Grinberg K.N., Debov S.S.
PubMed Id: 6880116
Year: 1983 vol: 29  issue:3  pages: 25-29
Abstract: Collagen production was studied in human embryonal fibroblasts. Synthesis of collagen in the cells with trisomy 7 was decreased 2-fold as compared with diploid cells in spite of 50% increase of the collagen genes localized on the chromosome 7. Diploid and aneuploid cells synthesized collagens of the I and III types at similar weight ratios. At the same time, an increase in synthesis of type I collagen trimer was found in culture of cells with anomalous caryotype. A decrease of collagen production in cells with anomalous caryotype appears to be one of the reasons responsible for spontaneous abortion.
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Reference: Del'vig A.A., Kukharenko V.I., Grinberg K.N., Debov S.S., Absence of a gene dose effect for collagen type I and III in fibroblasts with trisomy of chromosome 7 from a spontaneously aborted human fetus, Voprosy meditsinskoi khimii, 1983, vol: 29(3), 25-29.
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