Voprosy meditsinskoi khimii (ISSN 0042-8809)

Effect of T-2 toxin on the activity of organelle-specific enzymes of various rat organs

   
Kravchenko L.V., Avren'eva L.I., Tutel'ian V.A.
PubMed Id: 6312690
Year: 1983 vol: 29  issue:4  pages: 113-117
Abstract: Dynamics of 5 marker enzymes activity from subcellular particles--succinate dehydrogenase, beta-glucosidase, arylsulphatases A and B, acid RNAase and glucose-6-phosphatase--were studied in liver, spleen, thymus and blood serum of rats after single intragastric administration of T-2 toxin at a dose of 3.8 mg/kg (LD50). The acute intoxication was accompanied by an early (within 1-3 hrs) and significant reduction of total proteins in the tissues studied. Distinct tissue- and organelle-tropic effects of T-2 toxin were found: the toxin induced a gradual decrease in activity of the enzymes studied in liver tissue, while selective activation of lysosomal hydrolases was observed in spleen and thymus tissues. The selective effect of T-2 toxin on spleen and thymus lysosomal hydrolases appear to be involved in the mechanism of action of the toxin.
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Reference: Kravchenko L.V., Avren'eva L.I., Tutel'ian V.A., Effect of T-2 toxin on the activity of organelle-specific enzymes of various rat organs, Voprosy meditsinskoi khimii, 1983, vol: 29(4), 113-117.
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