Voprosy meditsinskoi khimii (ISSN 0042-8809)

Characterization of clofibrate-stimulated alkaline phosphatase in rat liver

   
Popova S.V., Antonenkov V.D., Panchenko L.F.
PubMed Id: 6623998
Year: 1983 vol: 29  issue:4  pages: 78-83
Abstract: Hypolipidemic agent clofibrate induced the alkaline phosphatase activity in rat liver but did not affect this activity in kidney, brain, heart and intestine. In liver cells the clofibrate induced alkaline phosphatase was localized in plasma membrane and cytosol and was similar to the enzyme found in normal hepatocytes by its main properties (pH optimum, inactivation temperature, substrate specificity, Km, effect of inhibitors and inducers). The putative mechanism of the alkaline phosphatase induction in liver tissue by means of clofibrate is discussed.
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Reference: Popova S.V., Antonenkov V.D., Panchenko L.F., Characterization of clofibrate-stimulated alkaline phosphatase in rat liver, Voprosy meditsinskoi khimii, 1983, vol: 29(4), 78-83.
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