Voprosy meditsinskoi khimii (ISSN 0042-8809)

Maintenance of 2S retinol receptor in the retina of rats in injuries induced by visible light

   
Pokrovskiĭ B.V., Shabanova M.E., Gusman B.S., Fuks B.B.
PubMed Id: 6312695
Year: 1983 vol: 29  issue:4  pages: 87-91
Abstract: Male Wistar rats (140-150 g) were subjected to constant fluorescent light exposure (400 ft-cd) of 24 hrs-21 day; contents of rhodopsin, total soluble proteins, 2 S cytosolic receptor as well as the morphological (light microscopy) characteristics were studied in retina. After 24 hrs exposure content of rhodopsin was decreased by 82%, after 48 hrs--by 37% as compared with control level, and decreased down to zero value within the 20 day. The content of total cytosol proteins decreased more slowly and within 3 weeks constituted 68-72% as compared with the control level. There were progressive dystrophic changes of rods and cones within the third day, culminating in their destruction. 2 S receptor was determined by incubation of the cytosol with 2.0-6.0. 10(-8) M of 3H-retinol followed by sucrose gradient fractionation. During all the periods studied the 2 S receptor peak was observed. The data obtained suggest the maintenance of molecular mechanisms of vitamin A functioning in damaged retina.
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Reference: Pokrovskiĭ B.V., Shabanova M.E., Gusman B.S., Fuks B.B., Maintenance of 2S retinol receptor in the retina of rats in injuries induced by visible light, Voprosy meditsinskoi khimii, 1983, vol: 29(4), 87-91.
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